2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin.

It is commonly active in the 10–20 mg range, taken orally or nasally and highly dose-sensitive. Insufflating (snorting) requires a much lower dose, typically not exceeding 10 mg, but this method of consumption elicits an extremely painful sensation in the nasal cavity for 10 minutes or so. Shulgin classified 2C-E as a member of the "Magical Half-Dozen" in his book PiHKAL: A Chemical Love Story. Many have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense. Vivid visuals similar to those experienced while under the influence of LSD are common, and many reports indicate that the effects of this particular chemical may be overly intense for those not well experienced with psychedelics.

2C-E is intended for research and forensic purposes in a controlled laboratory for study only and is NOT intended for human consumption.